Fenech was born in Bône (now Annaba), in French Algeria to a Maltese father and Sicilian mother. From the late 1960s to early 1980s, Fenech starred in many types of European movies. She is best known for her erotic comedies, and began to work in that field in the late 1960s with Austrian director Franz Antel. Fenech also achieved fame with giallo and sex films such as Five Dolls for an August Moon, Your Vice Is a Locked Room and Only I Have the Key and Sex with a Smile, many of which were directed by Sergio Martino.
In the 1980s, she became a television personality, typically appearing with Barbara Bouchet on a chat show on Italian television. In the mid-1990s, she was engaged to the well-known Italian industrialist Luca di Montezemolo.
After many years of work in movie production (she produced, among others, The Merchant of Venice, 2004, with Al Pacino), Fenech accepted Quentin Tarantino's offer to star in another movie, Hostel: Part II (2007), directed by Eli Roth. A British general named Ed Fenech (played by Mike Myers) is a character in Tarantino's 2009 film Inglourious Basterds.
| 2025 | Il maestro |
| 2023 | Edwige, Queen of Giallo as self |
| 2023 | La quattordicesima domenica del tempo ordinario as Sandra Rubin |
| 2019 | George Hilton - Il mondo e' degli audaci as Herself |
| 2019 | All the Colors of Giallo as Self - Actress |
| 2010 | Celebrity Nude Revue: The Saucy 70's Volume 2 as (archive footage) |
| 2007 | Hostel Part II: A Legacy of Torture as Self |
| 2007 | Hostel Part II: The Next Level as Self |
| 2007 | Otel 2 as Art Class Professor |
| 2005 | Dark Fears Behind the Door as Herself |
| 2000 | Il fratello minore |
| 1988 | Un delitto poco comune as Hélène Martell |
| 1984 | Vacanze in America as signora De Romanis |
| 1982 | İdeal Bir Teklif as Patrizia |
| 1982 | Il Paramedico as Nina Miglio |
| 1982 | Çılgın Geceler as Francesca del Prà |
| 1981 | La poliziotta a New York as Gianna Amicucci / Pupa |
| 1981 | Cornetti alla crema as Marianna Tribalzi |
| 1981 | Tais-toi quand tu parles as Belle / Béatrix |
| 1981 | Asso as Silvia |
| 1981 | Il ficcanaso as Susanna |
| 1980 | Io e Caterina as Elisabetta |
| 1980 | Zucchero, miele e peperoncino as Amalia |
| 1980 | La moglie in vacanza... l'amante in città as Giulia |
| 1980 | Sono fotogenico as Cinzia Pancaldi |
| 1980 | Il ladrone as Debora |
| 1979 | La patata bollente as Maria |
| 1979 | Dottor Jekyll e gentile signora as Barbara Wimply |
| 1979 | La poliziotta della squadra del buon costume as Gianna D'Amico |
| 1979 | Sabato, domenica e venerdì as Ing. Tokimoto (episodio "Sabato") |
| 1978 | Amori miei as Deborah |
| 1978 | La soldatessa alle grandi manovre as Doctor Eva Marini |
| 1978 | Cazibeli as Luisa De Dominicis |
| 1978 | L'insegnante va in collegio as Monica Sebastiani |
| 1978 | Il grande attacco as Danielle |
| 1977 | La soldatessa alla visita militare as Eva Marini |
| 1977 | Taksici Kız as Marcella |
| 1977 | La vergine, il toro e il capricorno as Gioia Ferretti |
| 1976 | Ne Sevimli as Judge Viola Orlando / Rosa Orlando |
| 1976 | Çıldırtma Beni as Francesca Marani |
| 1976 | La poliziotta fa carriera as Gianna Amicucci |
| 1976 | 40 gradi all'ombra del lenzuolo as Emilia Chiapponi (episodio "La Cavallona") |
| 1976 | La dottoressa del distretto militare as Doctor Elena Dogliozzi |
| 1975 | Şen Dullar as Suzie |
| 1975 | Soy ve Öldür as Magda Cortis |
| 1975 | Canım Benim as Giovanna Pagaus |
| 1975 | La moglie vergine as Valentina |
| 1975 | Grazie… Nonna as Marianna Persichetti |
| 1974 | La signora gioca bene a scopa? as Eva |
| 1974 | Haram as Carmela Paternò |
| 1973 | Anna, quel particolare piacere as Anna Lovisi |
| 1973 | Dio, sei proprio un padreterno! as Orchidea |
| 1973 | La vedova inconsolabile ringrazia quanti la consolarono as Caterina Prevosti |
| 1973 | Giovannona Coscialunga disonorata con onore as Giovannona Coscialunga in arte Cocò |
| 1973 | Fuori uno sotto un altro, arriva il Passatore as Mora |
| 1972 | Quel gran pezzo dell'Ubalda tutta nuda e tutta calda as Ubalda |
| 1972 | Quando le donne si chiamavano 'Madonne' as Giulia |
| 1972 | Beş Damla Kan as Jennifer Lansbury |
| 1972 | Gece Ziyaretçisi as Floriana |
| 1972 | La bella Antonia, prima Monica e poi Dimonia as Antonia |
| 1972 | Yılan Ruhlu Kadının Kâbusu as Jane Harrison |
| 1971 | Le calde notti di Don Giovanni as Aiscia |
| 1971 | Deserto di fuoco as Juana / Actress |
| 1971 | Yılan Ruhlu Kadın as Julie Wardh |
| 1970 | Le Mans - Scorciatoia per l'inferno as Cora |
| 1970 | Don Franco e Don Ciccio nell'anno della contestazione as Anna Bellinzoni |
| 1970 | 5 bambole per la luna d'agosto as Marie Chaney |
| 1970 | Satiricosissimo as Poppea Sabina |
| 1969 | Die nackte Bovary as Emma Bovary |
| 1969 | Der Mann mit dem goldenen Pinsel as Hong-Kong |
| 1969 | Testa o croce as Manuela |
| 1969 | Madame und ihre Nichte as Yvette |
| 1969 | Top Sensation as Ulla |
| 1969 | Alle Kätzchen naschen gern as Blande |
| 1969 | Komm, liebe Maid und mache as Felicita |
| 1969 | Frau Wirtin hat auch eine Nichte as Rosalie Bobinet |
| 1968 | Frau Wirtin hat auch einen Grafen as Celine |
| 1968 | Il figlio di Aquila Nera as Nastacia |
| 1968 | Samoa, regina della giungla as Samoa |
| 1967 | Toutes folles de lui as Gina |
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